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인쇄

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2025
Abstract
Mitochondria are organelles with double-membrane structure of inner and outer membrane, which provides main energy support for cell growth and metabolism. Reactive oxygen species (ROS) mainly comes from mitochondrial and can cause irreversible damage to cells under oxidative stress. Thus, mitochondrial homeostasis is the basis for maintaining the normal physiological function of cells and mitophagy plays a pivotal role in the maintenance of mitochondrial homeostasis. At present, to enhance the sensitivity of cancer cells to radiotherapy and chemotherapy by regulating mitochondria has increasingly become a hot spot of cancer therapy. It is particularly important to study the effect of ionizing radiation (IR) on mitochondria and the role of mitophagy in the radiosensitivity of cancer cells. Most of the existing reviews have focused on mitophagy-related molecules or pathways and the impact of mitophagy on diseases. In this review, we mainly focus on discussing the relationship between mitophagy and radiosensitivity of cancer cells around mitochondria and IR.
- Book : 150(1)
- Pub. Date : 2025
- Page : pp.14
- Keyword :
2025
Purpose
Among all primary breast tumors, malignant phyllodes tumor of the breast (MPTB) make up less than 1%. In the treatment of phyllode tumors, surgical procedures such as mastectomy and breast-conserving surgery are the mainstay. MPTB has, however, been controversial when it comes to treating it with RT. We aimed to explore the prognostic impact of RT and other clinicopathologic factors on long-term survival for patients with stage T3 or T4 malignant phyllodes tumors.
Methods
We select patients with stage T3 or T4 MPTB who qualified for the criteria between 2000 and 2018 via the Surveillance, Epidemiology, and End Results (SEER) database. We performed 1:1 propensity score matching (PSM) and Kaplan–Meier analysis to explore the role of RT in long-term survival of patients with stage T3 or T4 MPTB. A univariate and multivariate analysis of breast cancer-specific survival (BCSS) and overall survival (OS) risk factors was carried out using a Cox proportional hazards model. In addition, the nomogram graph of OS and BCSS was constructed.
Results
A total of 583 patients with stage T3 or T4 malignant phyllodes tumors were included in this study, of whom 154 (26.4%) received RT, and 429 (73.6%) were treated without RT. Before adjustment, between groups with and without RT, BCSS (p = 0.1) and OS (p = 0.212) indicated no significant difference respectively. Using of PSM, the two groups still did not differ significantly in BCSS (p = 0.552) and OS (p = 0.172). In multivariate analysis, age (p < 0.001), surgery of primary site (p < 0.001) and distant metastatic status (p < 0.001) were related to prognosis, while RT still did not affect BCSS (p = 0.877) and OS (p = 0.554).
Conclusion
Based on the SEER database analysis, the study suggests that the patients with stage T3 or T4 MPTB treated with RT after surgery didn't have significant differences in BCSS or OS compared to those not treated with RT.
- Book : 150(1)
- Pub. Date : 2025
- Page : pp.2
- Keyword :
2025
- Book : 151()
- Pub. Date : 2025
- Page : pp.469-483
- Keyword :
2025
- Book : 150()
- Pub. Date : 2025
- Page : pp.632-644
- Keyword :
2025
Abstract
Purpose
Concurrent chemoradiation has been the mainstay of treatment for cervix cancer. We aimed to evaluate the non-inferiority of hypofractionated chemoradiation.
Methods
This study was designed as a phase 2, 1:1 randomized, investigator-blinded, controlled, non-inferiority trial and we report the interim results after 50% accrual. Cervical cancer patients with FIGO stages IIA-IIIC were recruited from April 2021 to September 2022. The intervention consisted of 40 Gy of 3D-conformal radiation therapy (RT) in 15 fractions over 3 weeks. In the control group, patients received standard chemoradiation of 45 Gy in 25 fractions over 5 weeks. Both groups received concurrent weekly cisplatin (40 mg/m²). Intravaginal brachytherapy of 28 Gy in 4 weekly fractions was delivered starting 1 week after the end of chemoradiation. The primary outcome was complete clinical response(CCR) at 3 months. Secondary outcomes included acute gastrointestinal (GI), genitourinary(GU), skin, and hematologic toxicities. A p value less than 0.05 was considered significant for analyses.
Results
59 patients were randomized; 30 in the control group and 29 in the intervention group. 20/30 (66.7%) of the patients in the control group and 19/29 (65.5%) in the intervention group achieved a CCR (absolute difference of 0.011, 95% CI − 0.23 to 0.25, p value: 0.13). There was a significantly higher rate of acute grade ≥ 3 GI toxicity in the intervention group (27.6%) compared with the control group (6.7%) (p value 0.032).
Conclusions
Despite an absolute difference of 1.1% in the 3-month CCR, our interim analysis failed to show the non-inferiority of the hypofractionated chemoradiation. Due to the higher GI toxicities, we will continue this trial using intensity-modulated radiation therapy.
Registration number and date
ClinicalTrials.gov: NCT04831437, 2021.4.1.
- Book : 150(1)
- Pub. Date : 2025
- Page : pp.20
- Keyword :
2025
Abstract
The oscillating water column (OWC) is an economical and feasible type of wave energy converter with minimal maintenance costs which have been widely investigated. In this study, the effect of lipwalls for a shore-front OWC is investigated using dual boundary equation method (DBEM) and computational fluid dynamics (CFD) approaches. The boundary value problem is solved using the DBEM method within the framework of linear water wave theory. Whilst in the CFD approach, the volume-of-fluid (VOF) approach is used for simulating the numerical wave tank, with appropriate boundary conditions and regular wave inlet. The DBEM approach is beneficial to understand the complex phenomena inside the chamber, viz., radiation conductance and susceptance. It is inferred that case-B (vertical + shoreward-slant lipwall) is found to exhibit better performance for a wider range of non-dimensional wave frequencies due to its wave trapping configuration where the position of the lower lipwall is orthogonal. The CFD studies provide interesting insights into the optimal damping ratio concerning wave amplification factor at higher relative water depths, power output, and correlation of phase difference. Besides, the study reveals that the pressure and wave elevation inside the chamber are associated with the inhalation and exhalation process of air is attributed to the lower half of the lipwall.
- Book : 147(1)
- Pub. Date : 2025
- Page : pp.011201
- Keyword :
2024
Naringenin is a flavonoid with several biological activities already reported but with few biological applications in the pharmaceutical field. In this work, a new flavanone, called carboxymidamide (DCHA), synthesized through the condensation reaction between naringenin and aminoguanidine is structurally confirmed through spectroscopic analysis of nuclear magnetic resonance, mass spectrometry and Fourier transform infrared. DCHA was not toxic to human fibroblasts and inhibited macrophage activation in vitro. In vivo, it suppressed leukocyte migration in lipopolysaccharide (LPS)-induced peritonitis and reduced zymosan-induced paw edema. Molecular docking simulations of DCHA in the active site of the enzymes inducible nitric oxide synthase, cyclooxygenase-2 and phosphodiesterase type 4 indicate that the anti-inflammatory activity of this new flavanone can be explained by the inhibition of these target enzymes. This is the first work to present the synthesis of a flavonoid derivative with aminoguanidine that showed a high anti-inflammatory potential.
- Book : ()
- Pub. Date : 2024
- Page :
- Keyword :
2024
Media elektronik sudah menjadi bagian dari keseharian yang berada dekat dengan lingkungan kita, dimana media ini juga memancarkan radiasi berupa gelombang tidak tampak atau gelombang ektromagnetik. Dengan seringnya interaksi dengan media ini, memperbearkemungkinan seseorang terpapar radiasi dimana dapat memberikan efek negatif yangmembahayakan Kesehatan. Untuk itu dilaksanakan penyuluhan mengenai bahaya sinyal danradiasi ini, dimana pesertanya dalah guru sebagai pendidik yang empunyai pengaruh luas diMasyarakat. Hasil dari penyuluhan ini adalah lebih dari 88% peserta mendapatkan pemahamanyang baik sekali dan mengapresiasi isi materi yang diberikan serta kegiatan yang dilaksanakan. Electronic media has become a part of daily life that is close to our environment, where thismedia also emits radiation in the form of invisible waves or electromagnetic waves. Frequent interaction with this media increases the possibility of a person being exposed to radiation whichcan have negative effects that are harmful to health. For this reason, education is carried outregarding the dangers of signals and radiation, where the participants are teachers as educatorswho have a wide influence in society. The result of this workshop was that more than 88% ofparticipants gained a very good understanding and appreciated the content of the material provided and the activities carried out.
- Book : 8(2)
- Pub. Date : 2024
- Page : pp.118-124
- Keyword :
2024
Abstract 5-O-methylvisammioside (MeV), a phenolic compound found in the underground part (radix) Saposhnikovia divaricate (Turcz. ex Ledeb.) Schischk. (Apiaceae) in the early stage, has also been detected in the extract of Eranthis longistipitata(Ranunculaceae) in recent literature. In previous studies, it was discovered to have anti-inflammatory and neuroprotective activities. However, the potential mechanisms of MeV antidepressants remain unclear. In the present study, Network pharmacology was adopted to conduct drug-target networks following obtaining the shared targets between MeV and major depressive disorder (MDD) in multiple databases. The binding ability of the compound to the core target was verified through molecular docking. In addition, the biological processes and signaling pathways involved in the antidepressant effect of MeV by animal experiments. Our results were as follows: i) There were 85 shared targets of MeV & MDD in multiple public databases. The target protein with a higher degree in the protein-protein interaction (PPI) network was Proto-oncogene tyrosine-protein kinase Src (SRC). ii) Gene Ontology analysis showed that MeV treatment of MDD mainly involves the positive regulation of phosphorylation, the response to lipopolysaccharide, and other biological processes. It was closely related to the nuclear factor kappa B (NF-κB) signaling pathway. iii) MeV administration significantly alleviated depression-like behaviors and reduced microgliosis in mice by inhibiting SRC phosphorylation. The antidepressant effects of MeV may be attributed to the NF-κB signaling pathway. The results may contribute to demonstrating the effectiveness of MeV against MDD and facilitate the development of new traditional Chinese medicine ingredients.
- Book : ()
- Pub. Date : 2024
- Page :
- Keyword :
2024
Abstract In this article, a compact planar four port Multiple-Input-Multiple-Output (MIMO) antenna configuration with an electrical dimension of 0.44λ × 0.44λ has been presented for Ultra wideband (UWB) operation and other wireless communication services. The proposed MIMO antenna consists of four identical microstrip line fed octagonal shaped patch antenna which are placed orthogonally to each other. In order to obtain required impedance bandwidth and desired isolation between antenna elements, modifications are made on ground plane and a circular metallic stub is inserted at the center of substrate. All the identical antenna elements operate from 2.62GHz to 20GHz covering the entire frequency band allotted to UWB operation. The isolation between different antenna elements is also obtained more than 15dB for the entire frequency range of impedance bandwidth. The proposed design also exhibits suitable radiation pattern with sufficient amount of gain. Different diversity performance parameters of the proposed design are observed to be within accepted limit. The time domain performance of the proposed design is also analysed in terms of group delay which further confirms the application of the proposed design as a UWB MIMO antenna configuration.
- Book : ()
- Pub. Date : 2024
- Page :
- Keyword :

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