| 764238 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
717 Selective activation of CD8+ T cells by a CD8-targeted IL-2 results in enhanced anti-tumor efficacy and safety |
2021-11-01 |
10.1136/jitc-2021-sitc2021.717 |
Moynihan Kelly, Pappas Danielle, Park Terrence, Chen Wei, Ni Irene, Bessette Paul, Chin Mike, Schumacher Ton, Yeung Andy, Djuretic Ivana |
| 764237 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
716 NL-201 induces inflammation in a 'cold' tumor microenvironment through upregulation of MHC-I, expansion of the TCR repertoire, and potent antitumor activity when combined with PD-1 inhibition |
2021-11-01 |
10.1136/jitc-2021-sitc2021.716 |
Mortales Christie, Dutzar Benjamin, Chen Jerry, Chen Alex, Huard Justin, Blancas-Mejia Luis, Walkey Carl, Swanson Ryan |
| 764236 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
715 WTX-330 is an IL-12 pro-drug that is conditionally activated within the tumor microenvironment and induces regressions in mouse tumor models |
2021-11-01 |
10.1136/jitc-2021-sitc2021.715 |
Morris Kristin, Brodkin Heather, Hicklin Daniel, Ismail Nesreen, Nirschl Christopher, Salmeron Andres, Steiner Philipp, Steuert Zoe, Sullivan Jenna, Winston William |
| 764235 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
714 Selective expansion of antigen-specific CD8 T cells with engineered antigen presenting exosome |
2021-11-01 |
10.1136/jitc-2021-sitc2021.714 |
Yamano Tomoyoshi, Lyu Xiabing, Hanayama Rikinari |
| 764234 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
561 Triple checkpoint blockade, but not anti-PD1 alone, enhances the efficacy of engineered adoptive T cell therapy in advanced ovarian cancer |
2021-11-01 |
10.1136/jitc-2021-sitc2021.561 |
Anderson Kristin, Su Yapeng, Burnett Madison, Bates Breanna, Suarez Magdalia Rodgers, Ruskin Susan, Vakil Aesha, Voillet Valentin, Gottardo Raphael, Greenberg Philip |
| 764233 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
555 A high-throughput in situ screen to identify synergistic combinations of immune-oncology drugs with targeted and cytotoxic agents in a patient-derived humanized mouse model of renal cancer |
2021-11-01 |
10.1136/jitc-2021-sitc2021.555 |
Jonas Oliver, Oswald Eva, Lashuk Kanstantsin, Ahn Sebastian, Schuler Julia |
| 764232 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
554 The panorama of tumor intrinsic immune regulators exhibited by genome-wide CRPISR immune screen integrated with comprehensive clinical dataset analysis |
2021-11-01 |
10.1136/jitc-2021-sitc2021.554 |
Hou Jiakai, Wang Yunfei, Shi Leilei, Chen Yuan, Xu Chunyu, Saeedi Arash, Pan Ke, Bohat Ritu, Egan Nicholas, McKenzie Jodi, Mbofung Rina, Williams Leila, Yang Zhenhuang, Sun Ming, Liang Xiaofang, Ahnert Jordi Rodon, Varadarajan Navin, Yee Cassian, Chen Yiwen, Hwu Patrick, Peng Weiyi |
| 764231 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
552 Amphiphile-peptide boosting with FMC63-binding surrogate peptide mimotopes induces activation and potent effector function in CAR-T cells targeting CD19 |
2021-11-01 |
10.1136/jitc-2021-sitc2021.552 |
DeMuth Peter, Tavares Amy, Castano Ana |
| 764230 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
550 ARTACUS: An open-label, multicenter, phase 1b/2 study of RP1 in solid organ transplant recipients with advanced cutaneous malignancies |
2021-11-01 |
10.1136/jitc-2021-sitc2021.550 |
Luke Jason, Migden Michael, Chai-Ho Wanxing, Bolotin Diana, Wise-Draper Trisha, Poklepovic Andrew, Laux Douglas, Kheterpal Meenal, Verschraegen Claire, Collichio Frances, Lutzky Jose, Daniels Gregory, Tsai Katy, Navia Susan, Castro Henry, Bommareddy Praveen, Pirzkall Andrea, Coffin Robert |
| 764229 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
549 An RNA-lipoplex (RNA-LPX) vaccine demonstrates strong immunogenicity and promising clinical activity in a Phase I trial in cutaneous melanoma patients with no evidence of disease at trial inclusion |
2021-11-01 |
10.1136/jitc-2021-sitc2021.549 |
Loquai Carmen, Hassel Jessica, Brück Patrick, Derhovanessian Evelyna, Cuk Katarina, Lörks Verena, Sikorski Julian, Gold Maike, Maurus Daniel, Schwarck-Kokarakis Doreen, Kästner Marion, Weisenburger Thomas, Eller Ann-Kathrin, Attig Sebastian, Hempel Silvana, Oehm Petra, Omokoko Tana, Kranz Lena, Quinkhardt Juliane, Vogler Isabel, Liebig Inga, Renken Stephanie, Leierer Melanie, Müller Verena, Mitzel-Rink Heidrun, Miederer Matthias, Grabbe Stephan, Utikal Jochen, Kaufmann Roland, Sahin Ugur, Türeci Özlem |
