Lung ultrasound is increasingly used in neonatal intensive care units. We summarized the ultrasonographic patterns, features of most neonatal respiratory morbidities, and clinical application in neonates. Lung ultrasound is a non-invasive, radiation-free, and reproducible adjunct tool that can guide the clinical management of neonates presenting with respiratory distress.

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• Pub. Date : 2025
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ABSTRACTIntroductionRadiographer preliminary image evaluation (PIE) is a patient safety mechanism where radiographers provide a written comment describing potential pathology in radiographs they have acquired. This can assist emergency referrers in making a diagnosis when a radiologist's report is unavailable. The aim of this study was to evaluate the accuracy of radiographer PIE in interpreting paediatric trauma radiographs in an Australian emergency department.MethodsA randomised sample of paediatric radiographic examinations (aged 16 years and under) from January 2022 to June 2023 was retrospectively reviewed. The anatomical regions reviewed included the appendicular and axial skeleton, chest and abdomen. The PIE for each examination was compared to the radiologist report to indicate if the radiographer's evaluation was a true negative/positive or false negative/positive value. This was used to calculate mean sensitivity, specificity and diagnostic accuracy. Discrepant PIE interpretations were further investigated.ResultsA total of 498 PIEs were reviewed. The overall accuracy, sensitivity and specificity were 93.3%, 84.3% and 98.1%, respectively. Cases with no participation and those marked as unsure for pathology represented 0.4% and 2.6% of the sample, respectively. The extremities were identified as a region frequently misinterpreted.ConclusionRadiographers in this study maintained a high diagnostic accuracy in interpreting paediatric radiographs. PIE may complement the emergency referrer's diagnosis when a radiologist report is unavailable to promote appropriate and timely treatment for paediatric patients in the emergency department. Further research with a larger sample may support targeted training to improve PIE performance in regions frequently misinterpreted.

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• Pub. Date : 2025
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• Pub. Date : 2025
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Over 64 million people worldwide are affected by heart failure (HF), a condition that significantly raises mortality and medical expenses. In this study, we explore the potential of retinal optical coherence tomography (OCT) features as non-invasive biomarkers for the classification of heart failure subtypes: left ventricular heart failure (LVHF), congestive heart failure (CHF), and unspecified heart failure (UHF). By analyzing retinal measurements from the left eye, right eye, and both eyes, we aim to investigate the relationship between ocular indicators and heart failure using machine learning (ML) techniques. We conducted nine classification experiments to compare normal individuals against LVHF, CHF, and UHF patients, using retinal OCT features from each eye separately and in combination. Our analysis revealed that retinal thickness metrics, particularly ISOS-RPE and macular thickness in various regions, were significantly reduced in heart failure patients. Logistic regression, CatBoost, and XGBoost models demonstrated robust performance, with notable accuracy and area under the curve (AUC) scores, especially in classifying CHF and UHF. Feature importance analysis highlighted key retinal parameters, such as inner segment-outer segment to retinal pigment epithelium (ISOS-RPE) and inner nuclear layer to the external limiting membrane (INL-ELM) thickness, as crucial indicators for heart failure detection. The integration of explainable artificial intelligence further enhanced model interpretability, shedding light on the biological mechanisms linking retinal changes to heart failure pathology. Our findings suggest that retinal OCT features, particularly when derived from both eyes, have significant potential as non-invasive tools for early detection and classification of heart failure. These insights may aid in developing wearable, portable diagnostic systems, providing scalable solutions for personalized healthcare, and improving clinical outcomes for heart failure patients.

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• Pub. Date : 2025
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IntroductionSpectral detector Computed Tomography (SDCT) enables generation of virtual non-contrast (VNC) images derived from a post-contrast scan, as previously investigated in healthy dogs. This technique is especially promising for awake scanned rabbits where motion between the pre- and the post-contrast scans makes comparison challenging. This study aimed to determine the reliability of VNC images for assessing abdominal organs in 20 rabbits by evaluating their qualitative and quantitative parameters compared to true unenhanced (TUE) images. Our hypothesis were that the VNC series would be comparable to TUE series and that the quality of the VNC images would be equal to or even superior to the native images.MethodsAttenuation values of VNC and TUE series were assessed using a two one-sided t-test (TOST) and the signal-to-noise ratio was calculated for each ROI in the different series. Additionally, a qualitative assessment of the VNC images relative to TUE images was performed in consensus by a board-certified radiologist and a second year diagnostic imaging resident by evaluating the iodine subtraction, image quality and noise of VNC images based on a 5-point Likert scale.ResultsA total of 219 regions of interest (ROIs) where drawn in abdominal organs. 72.1% of the ROIs displayed differences of less than 15 Hounsfield Units (HU) between TUE and VNC images. The differences in attenuation values of TUE and VNC were statistically significant (p < 0.05) for ≤ 5 HU in the spleen, for ≤ 10 HU and ≤ 15 HU additionally in the liver, musculature and renal cortices. These findings support the equivalence between VNC and TUE images. An average score of 4.4 was achieved for iodine subtraction across all patients, which encompasses all organ values, with no individual patient scoring below 4.0.DiscussionVNC images present a promising alternative to TUE images for abdominal organs without pathology in rabbits with the benefit of eliminating motion between the compared series and reducing examination time and radiation exposure by replacing pre-contrast scans. Further research is necessary to demonstrate the applicability of the technique to morphologically diseased organs.

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No Brasil, todo Serviço de Medicina Nuclear precisa apresentar um memorial de blindagem aos órgãos reguladores antes da construção e do início de suas atividades. As dependências de instalações radiativas devem possuir blindagens suficientes para manter as doses recebidas pelo público e pelos Indivíduos Ocupacionalmente Expostos dentro dos níveis de referência estabelecidos pelas resoluções da Comissão Nacional de Energia Nuclear. A blindagem consiste na adoção de barreiras físicas adicionais às estruturas existentes, com intuito de atenuar a radiação ionizante proveniente das fontes existentes nas instalações, o que requer cálculos complexos devido às muitas variáveis envolvidas, uma vez que em medicina nuclear utilizam-se fontes não seladas de radiação ionizante e os próprios pacientes se tornam fontes radioativas. Poucos documentos até hoje foram publicados sobre o tema e, até o momento, não foi encontrada na literatura uma publicação que reúna de forma clara todas as informações e orientações necessárias para realização de cálculos de blindagem de instalações de medicina nuclear. O objetivo deste trabalho é apresentar um guia com bases metodológicas e uma linha de raciocínio lógica para realização de cálculos de blindagem em medicina nuclear no Brasil, reunindo as definições e considerações encontradas na literatura.

• Book : 19()
• Pub. Date : 2025
• Page : pp.799-799
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The Biofilm Onboard Radiation Exposure Assessment Lab In Space (BOREALIS) mission is a 6U CubeSat initiative funded by the Italian Space Agency under the ALCOR program, executed through a collaboration among the School of Aerospace Engineering of Sapienza University of Rome, Interdepartmental Centre for Industrial Aerospace Research (CIRI Aerospace) of the University of Bologna and Kayser Italia Srl. BOREALIS is equipped with a lab-on-chip payload for studying the effects of microgravity and ionising radiation on microbial biofilms, which are crucial for understanding and preventing persistent infections in space environments. The satellite will operate across multiple orbits, moving from low to medium Earth orbit, to distinctly analyse the impacts of radiation separate from microgravity. The required orbital transfer not only tests the autonomy of its on-board systems in challenging conditions but also places BOREALIS among the first and few CubeSats to have ever attempted such a complex manoeuvre. This study explores the systematic application of Model-Based Systems Engineering to satellite design, from conceptualisation to trade-offs, using a tradespace analysis approach supported by Monte Carlo simulations to optimise mission configurations against performance and cost. Additionally, the adaptability of Model-Based Systems Engineering tools and the reusability of such an approach for other satellite projects are discussed, illustrating the BOREALIS mission as a case study for small mission design considering constraints and requirements.

• Book : 12(3)
• Pub. Date : 2025
• Page : pp.256-256
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Erdheim–Chester disease (ECD) is a rare non-Langerhans cell histiocytosis characterised by multiorgan pathological histiocytic infiltration. Cardiac involvement occurs in 40–75% of patients and increases mortality. A 55-year-old woman with chest pain and dyspnoea was found to have an interatrial septal mass and aortitis suspicious for ECD without other organ involvement. After two inadequate transcatheter interatrial biopsies were obtained using ultrasound guidance alone, diagnostic samples were successfully obtained using intraprocedural frozen section examination. The patient started genotype-targeted treatment with good response. Biopsy confirmation of ECD is required to guide treatment; however, cardiac biopsies are uncommonly performed when other organs are affected. Our unique case of isolated cardiovascular involvement highlights how frozen sectioning with multimodal intraprocedural imaging guidance can improve diagnostic yield of endomyocardial biopsies. It also highlights how diagnosis of rare conditions requires careful multidisciplinary evaluation of affected organs, procedural risk and diagnostic yield. The use of frozen sectioning can improve diagnostic yield of endomyocardial biopsies.

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• Pub. Date : 2025
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Abstract Background While canonical anabolic and proteolytic pathways have been well examined in the context of skeletal muscle proteostasis, the roles of endoplasmic reticulum stress (ERS) and the induced unfolded protein response (UPR) are underappreciated. Thus, we aimed to determine whether aging and/or disuse atrophy in rats altered skeletal muscle ERS/UPR markers. Methods and Results Soleus (SOL) and plantaris (PLT) muscles of 3-month-old (mo), 6 mo, 12 mo, 18 mo, and 24 mo rats (9–10 per group, 48 in total) were analyzed for UPR proteins with further analysis performed on the protein CHOP. The gastrocnemius muscles of 4 mo rats that had undergone hindlimb immobilization (HLI, n = 12) or sham casting (CTL, n = 12) were analyzed for similar targets as well as more extensive CHOP-related targets. CHOP protein was greater in the PLT and SOL of 18 and 24 mo rats versus other age groups (P < 0.05). Moreover, negative correlations existed between CHOP expression and normalized PLT (R=-0.702, P < 0.001) and SOL (R=-0.658, P < 0.001) muscle weights in all rats analyzed at different ages. CHOP protein expression was also greater in the gastrocnemius of HLI versus CTL rats (P < 0.001), and a negative correlation existed between CHOP protein expression and normalized muscle weights in these rats (R=-0.814, P < 0.001). Nuclear CHOP protein levels (P < 0.010) and genes transcriptionally regulated by CHOP were also greater in HLI versus CTL rats (P < 0.001) implicating transcriptional activity of CHOP is elevated during disuse atrophy. Conclusions CHOP is operative during aging- and disuse-induced skeletal muscle atrophy in rodents, and more research is needed to determine if CHOP is a key mechanistic driver of these processes.

• Book : 52(1)
• Pub. Date : 2025
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