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2025
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2025
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2025
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2025
Abstract
Based on a sample of (2712.4 ± 14.3) × 106
ψ(3686) events collected with the BESIII detector, a partial wave analysis of the decay
$$ \psi (3686)\to \Lambda {\overline{\Sigma}}^0{\pi}^0 $$
ψ
3686
→
Λ
Σ
¯
0
π
0
+ c.c. is performed to investigate Λ* and Σ* resonances in the
$$ {\pi}^0{\overline{\Sigma}}^0 $$
π
0
Σ
¯
0
and π
0Λ invariant mass distributions. Significant contributions are found from the Λ(1405), Λ(1520), Λ(1600), Λ(1670), Λ(1690), Λ(1800), Λ(1890), Λ(2325), Σ(1385), Σ(1660), Σ(1670), Σ(1750), and Σ(1910). The masses, widths, and production branching fractions for each component are determined. In addition, the branching fraction of
$$ \psi (3686)\to \Lambda {\overline{\Sigma}}^0{\pi}^0 $$
ψ
3686
→
Λ
Σ
¯
0
π
0
+ c.c. is measured to be (1.544 ± 0.013 ± 0.071) × 10
−4 for the first time, where the first uncertainty is statistical and the second systematic.- Book : 2025(2)
- Pub. Date : 2025
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2025
Background and Objectives: Single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is a well-established technique for evaluating myocardial perfusion and function in patients with suspected or known coronary artery disease. While conventional dual-detector SPECT scanners have limitations in spatial resolution and photon detection sensitivity, recent advancements, including full-ring solid-state cadmium zinc telluride (CZT) detectors, offer enhanced image quality and improved diagnostic accuracy. This study aimed to compare the performance of Veriton-CT, a full-ring CZT SPECT system, with GE Discovery 530c, a dedicated cardiac fixed-angle gamma camera, in myocardial perfusion imaging and their correlation with coronary angiography findings. Materials and Methods: This was a prospective study that analyzed 21 patients who underwent MPI at the Department of Nuclear Medicine, Lithuanian University of Health Sciences, Kauno Klinikos. A one-day stress–rest protocol using 99mTc-Sestamibi was employed, with stress testing performed via bicycle ergometry or pharmacological induction. MPI was first conducted using GE Discovery 530c (GE Health Care, Boston, MA, USA), followed by imaging on Veriton-CT, which included low-dose CT for attenuation correction. The summed stress score (SSS), summed rest score (SRS), and summed difference score (SDS) were analyzed and compared between both imaging modalities. Coronary angiography results were retrospectively collected, and lesion-based analysis was performed to assess the correlation between imaging results and the presence of significant coronary artery stenosis (≥35% and ≥70% narrowing). Image quality and the certainty of distinguishing the inferior myocardial wall from extracardiac structures were also evaluated by two independent researchers with differing levels of experience. Results: Among the 14 patients included in the final analysis, Veriton-CT was more likely to classify MPI scans as normal (64.3%) compared to GE Discovery 530c (28.6%). Additionally, Veriton-CT provided a better assessment of the right coronary artery (RCA) basin, showing greater agreement with coronary angiography findings than GE Discovery 530c, although the difference was not statistically significant. No significant differences in lesion overlap were observed for the left anterior descending artery (LAD) or left circumflex artery (LCx) basins. Furthermore, the image quality assessment revealed slightly better delineation of extracardiac structures using Veriton-CT (Spectrum Dynamics Medical, Caesarea, Israel), particularly when evaluated by an experienced researcher. However, no significant difference was observed when assessed by a less experienced observer. Conclusions: Our findings suggest that Veriton-CT, with its full-ring CZT detector system, may offer advantages over fixed-angle gamma cameras in improving image quality and reducing attenuation artifacts in MPI. Although the difference in correlations with coronary angiography findings was not statistically significant, Veriton-CT showed a trend toward better agreement, particularly in the RCA basin. These results indicate that full-ring SPECT imaging could improve the diagnostic accuracy of non-invasive MPI, potentially reducing the need for unnecessary invasive angiography. Further studies with larger patient cohorts are required to confirm these findings and evaluate the clinical impact of full-ring SPECT technology in myocardial perfusion imaging.- Book : 61(4)
- Pub. Date : 2025
- Page : pp.665-665
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2025
Background Research with neutrons is usually related to the use of fission-based research reactors or neutron spallation sources to offer neutron beams for science and industry. In recent years a novel way for the production of brilliant cold, thermal, and epithermal neutron beams has emerged with the availability of high current proton accelerator systems. These “High-Current Accelerator-driven Neutron Sources” (HiCANS) offer pulsed neutron beams with high peak brilliance close to present day neutron sources. Methods A project was launched at the Jülich Centre for Neutron Science for the development, design and demonstration of such an innovative high-current accelerator driven neutron source termed “High-Brilliance neutron Source” (HBS). The aim of the project is to construct a scalable neutron source as a user facility. The basic technical components consist of i) a high current proton accelerator with a proton energy below 100 MeV, ii) a compact neutron target, moderator and reflector unit and iii) a neutron extracting, and transport system optimized for neutron beams with high brilliance to serve a suite of high performing instruments with epithermal, thermal and cold neutrons for various applications. Results and Conclusions The HBS project will offer open access and services to the various and changing demands the scientific and also the industrial community asks for. The project offers flexible solutions to a broadest scale of applications in science and industry. The conceptual design of HBS as well as the technical design was published recently in a series of reports as blueprint of a HiCANS facility. HBS will complement and develop further the landscape of high-end neutron facilities in Europe. In addition, HBS will allow intense training and preparation for experiments at the highest level at flagship European neutron sources such as the ILL or, in the future, at the ESS.- Book : 3()
- Pub. Date : 2025
- Page : pp.10-10
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2025
Background: Traumatic brain injury (TBI) represents a significant global health concern, leading to substantial mortality and long-term disability. The intricate pathophysiology of TBI involves primary mechanical damage followed by a cascade of secondary injury events, including neuroinflammation, apoptosis, and oxidative stress. The nuclear factor kappa B (NF-κB) signaling pathway plays a pivotal role in orchestrating the inflammatory response post-TBI and has emerged as a potential therapeutic target. This preclinical study aimed to investigate the efficacy of NeuroAid™ (MLC601), a traditional herbal medicine, in modulating NF-κB expression and improving outcomes in a rat model of TBI.
Methods: This study employed a true experimental in vivo design with a post-test only control group. Male Wistar rats (n=18) were randomly divided into two groups: a control group (n=9) subjected to TBI via a weight-drop method, and an experimental group (n=9) subjected to the same TBI procedure followed by intraperitoneal administration of NeuroAid™ (MLC601) at a dose of 2.5 mg/kg body weight at 5 minutes, 8 hours, and 16 hours post-injury. NF-κB expression in brain tissue samples collected 1 hour after the final dose was assessed using immunohistochemistry and quantified by an immunoreactivity score considering both the intensity and percentage of NF-κB expression.
Results: Immunohistochemical analysis revealed the presence of NF-κB expression in both the nucleus and cytoplasm of neurons in both the control and experimental groups. While the experimental group treated with NeuroAid™ (MLC601) exhibited a lower average immunoreactivity score (0.93) compared to the control group (1.29), the difference in NF-κB expression between the two groups was not statistically significant (p = 0.122).
Conclusion: In this preclinical study using a Wistar rat model of TBI, the administration of NeuroAid™ (MLC601) did not result in a statistically significant reduction in NF-κB expression compared to the untreated control group. Although a trend towards lower NF-κB expression was observed in the NeuroAid™-treated group, further research with larger sample sizes, different dosages, and extended treatment durations is warranted to fully elucidate the potential therapeutic effects of NeuroAid™ (MLC601) in the management of traumatic brain injury.- Book : 9(6)
- Pub. Date : 2025
- Page : pp.7728-7740
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2025
In this study, a particle image velocimetry (PIV) system was used in a large circulating water tank to investigate the wake of a horizontal-axis tidal turbine model, focusing on minor blockage effects and scale influence. A wake map of the turbine was constructed based on PIV measurements, using velocity deficit, turbulence intensity (TI), and turbulence kinetic energy (TKE) as key indicators. The results showed that TKE developed later than TI, forming a plateau-like shape. This plateau was considered the decay region, with the transition and far-wake regions located before and after it, respectively. Additionally, the power law exponent of TI decreased from −0.731 in the decay region to −0.765 in the far wake, indicating a steeper decay further downstream. Overall, the wake map of the tidal stream turbine model exhibited similarities to that of a previously reported wind turbine model.- Book : 18(7)
- Pub. Date : 2025
- Page : pp.1870-1870
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