Disclosed herein is a system that addresses all of the current challenges described above by combining three existing technologies and an improved nuclear RNA delivery system to generate a first-in-class cellular therapy that can secrete a cancer specific suicide gene for the treatment of several cancers. Also disclosed herein is a 'Trojan-Horse' like genetic construct aimed at engineering a chemo-sensitive dominant clone for adaptive therapy in cancers, such as leukemia. In some embodiments, cells, such as cancer cells from a subject, are engineered with suicide genes to promote a bystander effect in neighboring cancer cells once returned to the subject. In some embodiments, these cells are further engineered to be clonally dominant, e.g. by deleting or mutating tumor suppressor genes in the cells, overexpressing oncogenes, or any combination thereof. Once the engineered cells have reached a target clonal dominance, the suicide gene can be induced, thereby promoting the bystander effect.

• 출원번호 : US2024/044629
• 출원인 : H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE INC.
• 특허번호 :
• IPC : C12N-005/0781(2010.01);C12N-015/86(2006.01);A61K-031/711(2006.01);A61K-048/00(2006.01);A61P-035/00(2006.01);C07K-014/155(2006.01);C07K-014/705(2006.01);C07K-005/10(2006.01);

An active thermal switch assembly according to aspects described herein may include a hot plate, a cold plate, and an actuator. The actuator may cause the hot plate and the cold plate to come into mechanical contact, thereby achieving a closed state for the active thermal switch and facilitating conductive heat transfer between the two plates. Convective/radiative heat transfer may have little effect as compared to conductive heat transfer (e.g., as may be the case in environments having reduced or no atmospheric pressure), such that operating the actuator to introduce a gap between the hot plate and the cold plate (thus achieving an "open" state) substantially reduces conductive heat transfer between the hot and cold plates accordingly. Controlling the separation distance between the hot plate and cold plate may also be used as a method to modulate the thermal radiation between the two surfaces.

• 출원번호 : US2024/044784
• 출원인 : GEMER, Andrew Josef;CYRUS, Justin;CYRUS, Julian;WILSON, Peter;FLECHT, Tobias;
• 특허번호 :
• IPC : H01H-037/72(2006.01);H01H-089/04(2006.01);

PROBLEM TO BE SOLVED: To assist a producer in cultivating fruits and vegetables.SOLUTION: The present invention relates to a cultivation auxiliary program for assisting in cultivating fruits, vegetables, etc., in a greenhouse, and the program causes a computer to execute processing of: receiving input of information on atmospheric temperature, amounts of solar radiation, and CO2 concentration in the greenhouse in future; estimating photosynthesis amounts and growth amounts of fruits, vegetables, etc., at a certain time point or period in future through simulation using the information on the atmospheric temperature, the amounts of solar radiation, and the CO2 concentration in the greenhouse in future; and identifying and display adjustment information on the atmospheric temperature in the greenhouse and/or adjustment information on planting density of the fruits, vegetables, etc., based upon balance between the estimated photosynthesis amount and growth amount.SELECTED DRAWING: Figure 13

• 출원번호 : 2024149367
• 출원인 : NATIONAL AGRICULTURE AND FOOD RESEARCH ORGANIZATION
• 특허번호 :
• IPC : G06Q-050/02(2024.01);A01G-007/00(2006.01);

A radiation system comprising a deformable minor having a reflective surface arranged to receive and reflect a laser beam to form a reflected laser beam, a beam splitter arranged to separate the reflected laser beam into a first portion and a second portion, a sensor, a focusing system configured to form an image of the reflective surface at the sensor using the first portion of the reflected laser beam, the sensor being configured to output beam data representative of the reflected laser beam, means for generating radiation using the second portion of the reflected laser beam, and a controller operable to cause the deformable mirror to deform the reflective surface based on the beam data.

• 출원번호 : EP2024/074269
• 출원인 : ASML NETHERLANDS B.V.
• 특허번호 :
• IPC : G03F-007/00(2006.01);H05G-002/00(2006.01);

A system comprising a multibeam antenna inside an enclosure with at least one radio unit mounted on the enclosure. The system is configured to be mounted at the distal end of a mast extending from a platform of a mobile base station, such that, when the mast is deployed, the antenna and the at least one radio are elevated together. The system may be configured for direct mounting at a predetermined elevation in a permanent or semi-permanent manner. Preferably, the radio(s) are mounted on the antenna in a position that reduces the length of the connector(s) required. The radio(s) may be mounted on the rear side of the enclosure. A non-metal back panel of the enclosure may be coated with a conductive coating to maximize FBR (front-to-back ratio of the antenna radiation).

• 출원번호 : US2024/044752
• 출원인 : GALTRONICS USA, INC.
• 특허번호 :
• IPC : H01Q-001/12(2006.01);H01Q-025/00(2006.01);H01Q-021/06(2006.01);H01Q-001/42(2006.01);H01Q-003/34(2006.01);

The large concrete container cutting, dismantling, and disposal suitability evaluation system according to an embodiment of the present invention comprises: a vertical and horizontal cutting device for a large concrete container and a solidified material, the device being capable of vertically and horizontally cutting a concrete container and a solidified material; a cut block separation device for separating a solidified material block, a grounding concrete block, and an external container block from the cut container and the solidified material cut blocks produced by the vertical and horizontal cutting device for a container and a solidified material; and a suitable disposal device for determining self-disposal or disposal suitability for each of the solidified block, the grounding concrete block, and the external container block individually separated by the cut block separation device, the suitable disposal device enabling self-disposal or disposal when the self-disposal or disposal suitability is satisfied..

• 출원번호 : KR2024/013095
• 출원인 : KOREA HYDRO &NUCLEAR POWER CO., LTD.;
• 특허번호 :
• IPC : G21F-009/30(2006.01);G21F-005/12(2006.01);G21F-005/002(2006.01);G01T-001/02(2006.01);

Provided are: an actinic ray-sensitive or radiation-sensitive resin composition containing solvent and a resin (X) having a repeating unit (u1), wherein the repeating unit (u1) includes a cation having a specific structure and an anion bonded to the molecular chain of the resin (X), and the content of the repeating unit (u1) is 40 mass% or more relative to the total amount of resin contained in the actinic ray-sensitive or radiation-sensitive resin composition; a resist film using the actinic ray-sensitive or radiation-sensitive resin composition; a pattern formation method; and an electronic device manufacturing method.

• 출원번호 : JP2024/031258
• 출원인 : FUJIFILM CORPORATION
• 특허번호 :
• IPC : G03F-007/004(2006.01);C08F-012/02(2006.01);C08F-020/10(2006.01);G03F-007/20(2006.01);G03F-007/039(2006.01);

A rail-type large concrete drum cutting and dismantling system according to one embodiment of the present invention comprises: a moving rail on which a large concrete drum, which is radioactive wastes, is loaded to be linearly moved to a predetermined position; a rotary platform which is disposed at the predetermined position, and sequentially rotates, at a predetermined angle, according to a predetermined cutting and dismantling control program, the large concrete drum moved along the moving rail; guide rail devices, which are provided at an interval in the vicinity of the rotary platform, disposes a cutting device at a predetermined height with respect to the rotary platform, and moves same by a predetermined angle at the predetermined height; a cutting and dismantling device for cutting and dismantling the large concrete drum while moving by a predetermined angle along the guide rail devices; and a control device for remotely controlling the moving rail, the rotary platform, the guide rail devices, and the cutting and dismantling device according to the cutting and dismantling control program.

• 출원번호 : KR2024/013096
• 출원인 : KOREA HYDRO &NUCLEAR POWER CO., LTD.;
• 특허번호 :
• IPC : G21F-009/30(2006.01);G21F-005/12(2006.01);G21F-005/002(2006.01);G21F-005/005(2006.01);

An image processing apparatus includes at least one processor that is configured to: acquire projection images obtained by imaging a subject with radiation at a plurality of angles; reconstruct a plurality of tomographic images from the acquired projection images; detect a plurality of structures of interest from the plurality of reconstructed tomographic images; and determine a priority for each of the structures of interest having the same type among the plurality of detected structures of interest by using a mutual relationship with other structures of interest.

• 출원번호 : 18820274
• 출원인 : FUKUDA, Wataru
• 특허번호 :
• IPC : G06T-007/00(2006.01);A61B-006/00(2006.01);A61B-006/03(2006.01);A61B-006/04(2006.01);A61B-006/50(2006.01);G06T-011/00(2006.01);G06V-010/75(2006.01);

An optoelectronic device with reduced optical losses is disclosed. The optoelectronic device includes a set of n-type layers; an active region that includes at least one quantum well configured to generate radiation at a peak emitted wavelength and at least one barrier; and a set of p-type layers disposed on the active region. A reflective layer can be disposed on the set of p-type layers. The set of p-type layers can included an electron blocking region, and a thickness of the electron blocking region can be 80% or less than a thicking of the set of p-type layers. Additionally, a thickness of the at least one barrier can be 20% or less than the thickness of the set of p-type layers.

• 출원번호 : 18821093
• 출원인 : Dion, Joseph
• 특허번호 :
• IPC : H01L-033/00(2006.01);H01L-033/04(2006.01);H01L-033/06(2006.01);H01L-033/10(2006.01);H01L-033/14(2006.01);H01L-033/32(2006.01);