By taking silt clay as the research object, two-phase electrode resistivity tests under different water content and dry density conditions were carried out to clarify the resistivity variation law and influence mechanism of silt clay. The results show that the resistivity of the soil decreases sharply in the low moisture content section then tends to stabilize with the change of moisture content, and decreases continuously with the increase of dry density. There are three phases of a medium, namely soil, water and air, in unsaturated soil, so there are mainly three conductive paths: between soil particles, between pore fluids, and between soil-water coupling. Under different moisture content and dry density conditions, there are obvious differences in the effective contact area, and the types and numbers of conductive paths, which in turn affect the resistivity of the soil. The water status and pore structure of the silt clay samples were analyzed by hydrogen nuclear magnetic resonance (1H-NMR) results to clarify the conductive mechanism of unsaturated silt clay. Finally, a volumetric moisture content and resistivity model is established to unify the effects of moisture content and dry density on resistivity, providing a theoretical reference for the construction and operation safety of silt clay engineering.

• Book : 20(4)
• Pub. Date : 2025
• Page : pp.e0319072-e0319072
• Keyword :

• Book : 124()
• Pub. Date : 2025
• Page : pp.104050-104050
• Keyword :

ABSTRACT Objective: The primary aim of radiation therapy planning is to achieve optimal tumor control probability (TCP) while minimizing the risk of normal tissue complications (NTCPs). Traditionally, the dose–volume histogram has been a reliable tool for evaluating volumetric dose distribution in treatment plans. This study aims to assess the radiobiological efficacy of volumetric modulated arc therapy (VMAT), step-and-shoot intensity-modulated radiation therapy (ss-IMRT), and dynamic IMRT (d-IMRT) in the treatment of thoracic tumors. Materials and Methods: This study involved 13 patients diagnosed with squamous cell carcinoma of the thorax. Thirteen patients with squamous cell carcinoma of the thoracic site were included in this study. For each patient, three treatment plans (VMAT, ss-IMRT, and d-IMRT) were created, and the corresponding radiobiological parameters, such as equivalent uniform dose (EUD), TCP, and NTCP, were computed using Niemierko and LKB model for all 39 treatment plans using BIOSUITE software. Results: The estimated average TCPs for ss-IMRT, d-IMRT, and VMAT are 61.51%, 62.86%, and 63.09%, respectively. Moreover, the average NTCPs observed for the organ at risk, lung, for ss-IMRT, d-IMRT, and VMAT were 3.27%, 1.96%, and 1.29%, respectively. In terms of the spinal cord, the average NTCPs for ss-IMRT, d-IMRT, and VMAT were 0.07%, 0.0%, and 0.0%, respectively. For the heart, the average NTCPs for ss-IMRT, d-IMRT, and VMAT were 0.10%, 0.12%, and 0.13%, respectively. Conclusions: The findings of this study suggest that VMAT might give equivalent TCP with less NTCP when compared to IMRT. The development of treatment planning techniques based on radiobiological factors aided in the prudent selection of physical parameters to attain high TCP and low NTCP.

• Book : 21(1)
• Pub. Date : 2025
• Page : pp.131-136
• Keyword :

최근 스마트폰, 태블릿과 같은 휴대용 전자기기의 대중화에 따라, 디스플레이에서 방출되는 인공적인자외선의 위험성에 대한 경각심이 고조되고 있다. 자외선 흡수율이 높은 금속 산화물 기반의 기능성 필름이다양하게 제안되어 왔지만, 전통적인 레이어드 복합체로는 우수한 자외선 차단율과 높은 투명성을 동시에 구현하기가 쉽지 않다. 본 연구에서는 각설탕에서 유래된 미세다공성 구조를 활용하여, 3차원 네트워크 구조화된ZnO 박막이 삽입된 PDMS 기반의 나노복합체 필름을 소개한다. 이러한 3차원 나노복합체 필름은 내부의 3차원 이종 계면에서 발생하는 독특한 광학적 거동으로 인해 투명하면서도 우수한 자외선 차단 성능을 발현할수 있음이 입증되었다. 임의의 표면에 탈부착 가능한 3차원 나노복합체 필름은 향후 일시적인 자외선 차단을위한 악세서리형 광학 부품으로 활용될 수 있을 것이다.

• Book : 26(1)
• Pub. Date : 2025
• Page : pp.9-14
• Keyword :

• Book : ()
• Pub. Date : 2025
• Page : pp.101712-101712
• Keyword :

• Book : ()
• Pub. Date : 2025
• Page :
• Keyword :

With the advent of ever more intense and focused X-ray sources, including in laboratories, at synchrotrons, and at X-ray free electron lasers, radiation-induced sample change and damage are becoming increasingly...

• Book : ()
• Pub. Date : 2025
• Page :
• Keyword :

• Book : ()
• Pub. Date : 2025
• Page :
• Keyword :

Deinococcus radiodurans is a remarkably unique microorganism, exhibiting extraordinary tolerance to extreme conditions such as ionizing radiation, ultraviolet light, and desiccation. However, the response mechanisms of D. radiodurans under low-temperature stress remain largely unexplored and have yet to be fully elucidated. The DohD protein is a hydrophilic member of the late embryogenesis abundant 3 (LEA3) family of D. radiodurans, playing a pivotal role in abiotic stress adaptation. Bioinformatics analysis revealed that DohD contains tandem repeats and disordered domains, with a remarkably high α-helix content (91.41%). Furthermore, DohD exhibits extremely low homology with other proteins, highlighting its uniqueness to D. radiodurans. Under low-temperature stress (15 °C), the expression of dohD was significantly upregulated (5-fold), regulated by a dual mechanism involving positive control by DrRRA and negative regulation by Csp. Circular dichroism spectroscopy unveiled temperature-dependent structural plasticity: as the temperature increased from 0 °C to 50° C, the α-helix content decreased from 23.5% to 18.7%, while the antiparallel β-sheet content increased from 31.3% to 50.8%. This suggests an α-helix to β-sheet interconversion mechanism as a strategy for thermal adaptation. Additionally, deletion of dohD impaired the tolerance of D. radiodurans to cold, desiccation, oxidative, and high-salt stresses, accompanied by the reduced activities of antioxidant enzymes (SOD, CAT, POD) and the downregulation of related gene expression. This study elucidates the multifunctional role of DohD in stress resistance through structural dynamics, transcriptional regulation, and redox homeostasis, providing valuable insights into the adaptation mechanisms of extremophiles.

• Book : 26(8)
• Pub. Date : 2025
• Page : pp.3511-3511
• Keyword :

BackgroundNon-Small Cell Lung Cancer (NSCLC) patients with low tumor mutational burden (TMB) showed low sensitive to conventional fractionated radiotherapy in our previous study. This study aimed to evaluate the efficacy and safety of hypofractionated radiotherapy (HFRT) in locally advanced NSCLC patients with low-TMB compared to conventional fractionated radiotherapy (CFRT).MethodsWe retrospectively analyzed clinical outcomes of 74 locally advanced NSCLC patients with low-TMB undergoing definitive radiotherapy from January 2017 to July 2023, with 31 patients received HFRT (received radiation doses of >2Gy and ≤5 Gy per fraction) and 43 received CFRT (received radiation doses of 1.8-2 Gy per fraction). Progression-free survival (PFS), overall survival (OS) and objective response rate (ORR) to radiotherapy was analyzed in the two groups. Univariate analysis was performed to assess the impact of clinical characteristics on PFS. We also analyzed PFS in subgroups receiving HFRT or CFRT combined with immunotherapy and chemotherapy.ResultsSurvival analysis revealed the median PFS of 13 months in the HFRT group was significantly better than the 10 months in the CFRT group (p = 0.024). The 6-month and 12-month PFS rates were 80.6% and 61.3% for the HFRT group, versus 81.4% and 39.5% for the CFRT group, respectively. Median OS was 27 months in the HFRT group and 20 months in the CFRT group (p = 0.079). There were no statistically significant differences in major adverse events between the HFRT and CFRT groups (all p>0.05). In the subgroup receiving combined immunotherapy and chemotherapy, the median PFS was 10 months in the HFRT group and 9 months in the CFRT group (p = 0.092).ConclusionHFRT was superior to CFRT in prolonging PFS for patients with low-TMB locally advanced NSCLC. It was a safely and effective approach for these patients and was worth further prospective studies with larger sample sizes.

• Book : ()
• Pub. Date : 2025
• Page :
• Keyword :