The invention concerns compositions and a method for treating or delaying the onset, progression, or relapse of a cancer in a subject, the method comprising administering, optionally with radiation therapy, an inhibitor of: (a) DNA-Dependent Protein Kinase catalytic subunit, and an inhibitor of Poly-ADP Ribose Polymerase, wherein the cancer has a histone H3.3 mutation or is a homologous recombination-defective (HR-defective) cancer; or (b) wild-type isocitrate dehydrogenase, wherein the IDH inhibitor is administered in an effective amount to decrease wild-type IDH activity in cells of the cancer, and wherein the cancer carries a histone H3.3 K27M mutation, and/or the cancer has low DNA methylation and/or low histone methylation; or (c) histone acetyltransferase, wherein the cancer carries a histone H3.3 K27M mutation, and/or high histone acetylation; or (d) histone deacetylase, wherein the cancer carries a histone H3.3 K27M mutation, and/or has high histone acetylation; or (e) any combination thereof.

• 출원번호 : 18901200
• 출원인 : Gunjan, Akash
• 특허번호 :
• IPC : A61K-031/5377(2006.01);A61K-031/404(2006.01);A61K-031/4741(2006.01);A61K-031/517(2006.01);A61K-031/522(2006.01);A61K-045/06(2006.01);

An improved near-infrared spectroscopy based handheld tissue oxygenation scanner and method in which the handheld tissue oxygenation scanner is a small device-like an optical mouse-employing a single transmitter-receiver pair, an optical switch, and a plurality of optical fibers that transmit light into tissue under examination and receive light after interacting with that tissue. The integration of a plurality of optical fibers wherein each individual one provides emission/reception of infrared radiation advantageously provides a higher density of tissue interrogation by the infrared radiation thereby providing faster operation and more information in a given time period. Additional features and advantages of our inventive system and method include computer control and the ability to connect to a variety of computing devices via BlueTooth and other communications techniques.

• 출원번호 : 18901562
• 출원인 : NEC Laboratories America, Inc.
• 특허번호 :
• IPC : A61B-005/1455(2006.01);A61B-005/00(2006.01);

Techniques are described for contouring of a region of interest based on imaging parameters of spatial imaging data and guided by user input of locations in the spatial imaging data, which may be used for segmentation or radiation treatment planning. An approach is described of combining a new paint brush tool with an edge-detection algorithm to correct for both the jagged contours and the painting routine not being executed often enough. By using an edge-detection algorithm, the user does not need to focus as much attention on moving the mouse accurately because the system will find the true organ boundary (e.g., using the image gradient) automatically, which may also lead to more time savings.

• 출원번호 : 18902544
• 출원인 : Moreau, Michel
• 특허번호 :
• IPC : G06T-007/13(2006.01);G06T-017/20(2006.01);

Disclosed embodiments include fuel assemblies, methods of making a fuel element, and methods of using a fuel element. A fuel element includes fuel, a fuel liner, and a cladding. The liner may be formed of one, two, three, or more layers of different materials, including different alloys have a different primary metallic component. The cladding may likewise be formed of one, two, three, or more layers of different materials. The different materials may include different alloys, different compositions, and/or different alloys in which the primary constituent of the alloy is a different material.

• 출원번호 : 18901736
• 출원인 : Povirk, Gary
• 특허번호 :
• IPC : G21C-003/18(2006.01);G21C-003/07(2006.01);

PROBLEM TO BE SOLVED: To provide an image processing device, a radiation imaging system, an image processing method, and an image processing program capable of deriving an amount of positional deviation between projection images with a high degree of precision.SOLUTION: In an image processing device, a processor acquires a plurality of projection images; acquires a plurality of tomographic images generated using the plurality of projection images, which correspond to each of a plurality of tomographic surfaces of a subject; generates a plurality of reference material presence pseudo projection images including reference material images by performing pseudo projection from an irradiation position in settings corresponding to the irradiation position of each of the plurality of projection images using the tomographic image including the reference material image indicating the reference material used as a reference for deriving the amount of positional deviation between the projection images of the plurality of tomographic images; and derives the amount of positional deviation between the projection images on the basis of the plurality of projection images and the plurality of reference material presence pseudo projection images.SELECTED DRAWING: Figure 10

• 출원번호 : 2024171434
• 출원인 : FUJIFILM CORP
• 특허번호 :
• IPC : A61B-006/02(2006.01);A61B-006/50(2024.01);

The purpose of the present invention is to provide: a radiation sensitive composition which exhibits sensitivity and CDU at satisfactory levels when next generation techniques are used and which can form a resist film in which developing defects are suppressed; and a pattern formation method. Another purpose of the present invention is to provide a polymer and a compound able to be used in the radiation-sensitive composition. The present invention relates to a radiation-sensitive composition which contains: a polymer (A) including a structural unit (I) represented by general formula (1); and a solvent (B). The polymer (A) includes a radiation-sensitive acid-generating structural unit (IV): and/or a radiation-sensitive acid generator (C) is contained in a component other than the polymer (A). An iodo group is contained in at least one component selected from the group consisting of the polymer (A) and the radiation-sensitive acid generator (C). In formula (1), R is a hydrogen atom, a fluorine atom, a methyl group or a trifluoromethyl group. L is a single bond or a divalent linking group. Ar denotes a furan ring, a thiophene ring, or a 9- to 20-membered aromatic heterocyclic ring having a furan ring or a thiophene ring. R is a hydrogen atom or a monovalent organic group having 1-20 carbon atoms. R is a halogen atom, a hydroxyl group, a cyano group, a nitro group, an amino group, a thiol group or a monovalent organic group having 1-20 carbon atoms. n is an integer between 0 and 4. If the value of n is 2 or more, multiple R moieties may be the same as, or different from, each other.

• 출원번호 : JP2024/034915
• 출원인 : JSR CORPORATION
• 특허번호 :
• IPC : G03F-007/039(2006.01);C07D-307/68(2006.01);C07D-307/85(2006.01);C07D-333/38(2006.01);C07D-333/70(2006.01);C07D-407/12(2006.01);C07D-409/12(2006.01);C08F-008/12(2006.01);C08F-024/00(2006.01);C08F-028/00(2006.01);G03F-007/004(2006.01);G03F-007/20(2006.01);

Apparatus and methods are described for enhancing the tracking of sports related items using markers facilitating the identification by a tracking device of specific positions associated with these items so that the positions of the items during a striking process can be more accurately determined. For example, a system includes a tracking device tracking motion of a golf club and generating tracking data corresponding to a position of the club during a swing and a processor analyzing the data to identify a portion corresponding to a marker positioned on the club. The marker reflects a target type of radiation in a manner distinguishable from the reflection of radiation from portions of the club excluding the marker. The processor determines, based on the tracking data corresponding to the portions of the club excluding the marker and the tracking data corresponding to the marker, a three-dimensional trajectory of the club.

• 출원번호 : 18901346
• 출원인 : TUXEN, Fredrik
• 특허번호 :
• IPC : A63B-024/00(2006.01);A63B-102/32(2015.01);

An optoelectronic device includes, in a stack, an emitting layer having optically active structures, configured to emit or receive radiation, a sensitive layer having at least one structure having a temperature resistance below a temperature Tmax below 200° C., a bond layer, and a transparent support layer. The bond layer is based on an inorganic low temperature bonding material. The bond layer also has cavities directly in line with the optically active structures, between the transparent support layer and the sensitive layer.

• 출원번호 : 18901832
• 출원인 : ALEDIA
• 특허번호 :
• IPC : H01L-033/50(2010.01);H01L-025/16(2023.01);H01L-033/30(2010.01);

The invention relates to a method for the replication of a polychromatic hologram. The method involves providing a master assembly, comprising a first master hologram and a second master hologram which are arranged in a layer structure. The method also involves providing a replication assembly and aligning the first master hologram in relation to the replication assembly by translation and/or by rotation of the master assembly. The first master hologram is exposed by means of electromagnetic radiation of a first wavelength range in order to obtain a first replicated hologram in the replication assembly. In addition, the method involves aligning the second master hologram in relation to the replication assembly by translation and/or by rotation of the master assembly. The second master hologram is exposed by means of electromagnetic radiation of a second wavelength range in order to obtain a second replicated hologram in the replication assembly. The invention also relates to a replication assembly that can be produced by means of the method according to the invention. In addition, the invention relates to a master element and a device for carrying out the method according to the invention.

• 출원번호 : EP2024/077268
• 출원인 : CARL ZEISS JENA GMBH
• 특허번호 :
• IPC : G03H-001/20(2006.01);G03H-001/18(2006.01);G03H-001/22(2006.01);G03H-001/26(2006.01);

Methods, systems, and computer readable media are provided for reduced-dose angiography using machine learning (e.g., deep learning) with a concordance metric indicating a degree of similarity between an estimated segmentation of angiographic images generated by a machine learning model and segmented benchmark angiographic images provided as inputs to the machine learning model. Briefly, techniques described herein may use a neural network trained to conserve/preserve angiographic image quality while reducing the angiographic dose of potentially harmful chemical contrast and/or x-ray radiation by employing a concordance metric.

• 출원번호 : US2024/048938
• 출원인 : ANGIOWAVE IMAGING, INC.;BUTLER, William E.;
• 특허번호 :
• IPC : A61B-006/50(2024.01);G06T-007/10(2017.01);