The compositions and methods provided herein include a ribonucleic acid (RNA) encoding a nuclear cytoplasmic transport (NCT) inhibitor protein to improve target protein expression, e.g., a target protein encoded by a DNA vector, a messenger RNA, a self-amplifying RNA, or an RNA comprising an unmodified uridine nucleotide. The compositions and methods provided herein may be used to improve the expression of any target protein, for example a viral protein antigen for use in a vaccine.

• 출원번호 : 18893827
• 출원인 : Mertins, Barbara
• 특허번호 :
• IPC : A61K-039/125(2006.01);A61K-039/00(2006.01);A61P-029/00(2006.01);A61P-037/06(2006.01);C12N-007/00(2006.01);

Provided is a dynamic image processing apparatus that includes: at least one hardware processor; and an outputter that outputs information on a setting value of a respiratory assistance apparatus, and the at least one hardware processor extracts the information by processing at least one dynamic image imaged by irradiating lungs of a subject, who is put on the respiratory assistance apparatus, with radiation.

• 출원번호 : 18892719
• 출원인 : Konica Minolta, Inc.
• 특허번호 :
• IPC : G06T-007/00(2017.01)

Compounds, compositions and methods are provided for the inhibition of ENPP1. Aspects of the subject methods include contacting a sample with an ENPP1 inhibitor compound to inhibit the cGAMP hydrolysis activity of ENPP1. In some cases, the ENPP1 inhibitor compound is cell impermeable. ENPP1 inhibitor compounds can act extracellularly to block the degradation of cGAMP. Also provided are pharmaceutical compositions and methods for treating cancer. Aspects of the methods include administering to a subject a therapeutically effective amount of an ENPP1 inhibitor to treat the subject for cancer. In certain cases, the cancer is a solid tumor cancer. Also provided are methods of administering radiation therapy to a subject in conjunction with administering an ENPP1 inhibitor to the subject. The radiation therapy can be administered in the subject methods at a dosage and/or frequency effective to reduce radiation damage to the subject, but still instigate an immune response.

• 출원번호 : 18893468
• 출원인 : Li, Lingyin
• 특허번호 :
• IPC : C07F-009/6512(2006.01);A61K-031/44(2006.01);A61K-031/4706(2006.01);A61K-031/517(2006.01);A61K-031/675(2006.01);A61K-031/69(2006.01);A61K-045/06(2006.01);A61P-035/00(2006.01);C07D-215/46(2006.01);C07D-401/04(2006.01);C07F-005/02(2006.01);C07F-009/60(2006.01);C07F-009/6558(2006.01);

One or more example embodiments relates to an imaging system configured to record projection images, the imaging system comprising a detector unit; a radiation source, wherein the detector unit includes two detector elements arranged one behind the other, both of the two detector elements cover a same recording area, the two detector elements including a first detector element and a second detector element, and at least one of the radiation source or the detector unit is configured such that the second detector element is not saturated for sections of the recording area in which the first detector element is saturated during irradiation; and a data acquisition unit configured to record a first data set of the first detector element and to record a second data set of the second detector element such that first data set and the second data set are separable from one another.

• 출원번호 : 18892811
• 출원인 : Siemens Healthineers AG
• 특허번호 :
• IPC : G01T-001/24(2006.01);G01T-001/29(2006.01);

The invention relates to a magnetic field sensor (1) comprising an NV diamond (3), an excitation light source (4) which is designed to emit excitation radiation (5) for exciting electronic states of the NV diamond (3), a microwave structure (6) which is designed to generate a microwave field for manipulating spin states of the NV diamond (3), a detector (11) which is designed to detect fluorescence radiation which the NV diamond (3) can emit as a result of having been irradiated with the excitation radiation (5), and a magnetic field generating device (8) which is provided and designed to generate a permanent magnetic field in the region of the NV diamond (3), wherein the excitation light source (4), the microwave structure (6) and the magnetic field generating device (8) are located on a sensor board (2).

• 출원번호 : EP2024/076586
• 출원인 : ROBERT BOSCH GMBH
• 특허번호 :
• IPC : G01R-033/26(2006.01)

A radiation image capture apparatus including a plurality of pixels which include a detection pixel configured to detect an irradiation amount and an exposure decision unit configured to decide an amount of radiation irradiated from a radiation generation apparatus. The exposure decision unit decides the amount of irradiated radiation based on an output of the detection pixel during radiation irradiation and a correction value that is an output of the detection pixel while the radiation irradiation is not performed. The exposure decision unit obtains the correction value after a read operation of a signal based on radiation during image capture is performed, and in the subsequent image capture, the amount of irradiated radiation is decided based on the output of the detection pixel during the radiation irradiation and the correction value.

• 출원번호 : 18893623
• 출원인 : MORITA, HIDEAKI
• 특허번호 :
• IPC : G01T-001/29(2006.01);G01T-001/02(2006.01);G01T-001/17(2006.01);G01T-001/24(2006.01);G01T-007/00(2006.01);

Some aspects of the technology described herein are directed to a thermal sensor and corresponding systems and methods for mitigating errors arising from non-radiative heat flow. The thermal sensor system, comprising: a thermal sensor comprising and a housing. The thermal sensor comprising: a thermal detection region of a sensor substrate; a thermal reference region of the sensor substrate; and an array of thermocouples configured to detect a thermal differential between the thermal detection region and the thermal reference region. The housing configured to support the thermal sensor within the housing and beneath a windowed aperture of the housing, wherein the windowed aperture is configured such that radiative energy may transmit through the windowed aperture and be received by the thermal sensor.

• 출원번호 : 18893215
• 출원인 : Excelitas Technologies Singapore Pte. Ltd.
• 특허번호 :
• IPC : G01J-005/16(2006.01);G01J-005/06(2006.01);

Provided is a glutamic acid (Glu)-urea compound and a preparation method and use thereof. The Glu-urea compound and the nuclide-targeted probe have excellent in vivo biological properties and show a high specific uptake in lesions with high expression of a prostate-specific membrane antigen (PSMA) protein. The compound and probe have a high target/non-target ratio, low non-specific background activity, and significantly-enhanced tumor uptake and retention time. The compound and probe are suitable for use in the nuclide therapy and imaging of tumors, and can also reduce unnecessary radiation damage to normal tissues and organs. The compound and probe can also overcome the shortcomings such as low target organ uptake and short retention time of small-molecule PSMA, and improve the effects of PSMA-targeted nuclide therapy and imaging, thus exhibiting a potential to be widely used in clinical applications.

• 출원번호 : 18893474
• 출원인 : GUO, Zhide
• 특허번호 :
• IPC : A61K-051/08(2006.01);A61P-035/00(2006.01);

A system and method for reducing a number of cancerous cells in the body through use of a treatment package a mixture of scintillating organic silicon-based polymer and a nitric oxide (NO) release agent at least partially surrounded by a functional material that facilitates consumption of the treatment package by a macrophage. The macrophage travels to the tumor and is then radiated with X-ray radiation causing the scintillating polymer to emit photons at a first wavelength which strike and causing the release agent to release substance toxic to the cancer cells. The scintillating polymer may comprise polydimethylsiloxane. The release agents may comprise one or more of the following: iron, copper, CrONO, Ruthenium (phen)(NO)(Cl), and Roussin's black salt. The scintillating polymer is selected such that the emitted photon wavelength corresponds to a wavelength of maximum absorption by the release agent.

• 출원번호 : 18893773
• 출원인 : Tinsley, James R.
• 특허번호 :
• IPC : A61K-033/00(2006.01);A61K-009/50(2006.01);A61K-031/80(2006.01);A61K-035/15(2025.01);A61K-041/00(2020.01);

Multifunctional cerium oxide-P7C3 (aminopropyl carbazole) chimeric nanocompositions and methods for using these nanocompositions for enhancing bone deposition are provided. For example, these nanocompositions can be used to combat radiation-induced bone tissue/cell damage, to treat any disorders that promote osteoporosis, and/or to treat bone trauma/injury.

• 출원번호 : 18892448
• 출원인 : University of Central Florida Research Foundation, Inc.
• 특허번호 :
• IPC : A61K-047/69(2017.01);A61K-047/55(2017.01);A61P-019/10(2006.01);A61P-043/00(2006.01);