The present invention relates to peptides with 11-12 amino acids for use thereof as a medicine in cardiac diseases, especially ventricular arrhythmias in patients with cardiac hypertrophy, cardiac insufficiency (CI) and/or hereditary loss-of-function syndromes in the Nav1.5 or Kir2.1 channels. The peptide with 11 amino acids and the synthetic analogues with 11-12 amino acids include a nuclear localisation signal, activate transcription, prevent the decrease in the density of I and I caused by CI, and significantly increase the density of I and I in cases of CI. The invention also includes cDNA molecules that encode these peptides, the vectors and/or the cells containing them and pharmaceutical compositions containing same for use thereof in the prevention and/or treatment of cardiac diseases.
- 출원번호 : ES2024/070586
- 출원인 : UNIVERSIDAD COMPLUTENSE DE MADRID;CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS;CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.);
- 특허번호 :
- IPC : C07K-007/06(2006.01);C07K-014/47(2006.01);A61P-009/06(2006.01);C12N-015/09(2006.01);