The present invention relates to an heparanase-binding and heparanase-neutralizing monoclonal antibody (IgG-1 mAb A54), including its epitope (HBD-II) and mode of interaction with heparanase, pharmaceutical composition comprising same, and uses thereof e.g. for inhibiting or treating a disease or disorder associated with heparanase activity, including but not limited to cancer, inflammation, viral infection, diabetes and related complications. The present invention further provides combinatorial cancer therapies, comprising the heparanase-neutralizing mAb and an additional anti-cancer treatment such as chemotherapy or radiation.

• 출원번호 : 18895539
• 출원인 : Technion Research & Development Foundation Limited
• 특허번호 :
• IPC : C07K-016/40(2006.01);A61K-031/69(2006.01);A61K-031/7068(2006.01);A61K-039/00(2006.01);A61K-039/395(2006.01);A61P-035/00(2006.01);A61P-035/04(2006.01);

Organotin clusters are described with the formula R3Sn3(O2CR′)5−x(OH)2+x(μ3-O) with 0≤x2; R=branched or cycloalkyl with 1 to 31 carbon atoms; R′=H or alkyl with 1 to 20 carbon atoms. Three carboxylato ligands are bridging, and two OH ligands are bridging. The remaining two carboxylato ligands are in non-bridging configurations, and the non-bridging carboxylato ligands are exchangeable in solution. Solutions of these clusters are suitable for forming radiation sensitive coatings that can be used to pattern nanometer scale structures. The radiation sensitive coatings are particularly suitable for EUV patterning.

• 출원번호 : 18895654
• 출원인 : Cardineau, Brian J.
• 특허번호 :
• IPC : C07F-007/22(2006.01);G03F-007/004(2006.01);G03F-007/20(2006.01);G03F-007/32(2006.01);

A semiconductor device is provided, which includes an active structure, a first semiconductor layer, a second semiconductor layer, an insulating layer, and a conductive layer. The active region has two sides and includes an active region. The first semiconductor layer and the second semiconductor layer respectively located on the two sides of the active structure. The insulating layer covers a portion of the first semiconductor layer. The conductive layer covers the insulating layer and physically contacts the first semiconductor layer. The second semiconductor layer includes a first dopant and the first semiconductor layer includes a second dopant different from the first dopant. The first semiconductor layer includes a quaternary III-V semiconductor material, and the active region includes a quaternary semiconductor material, and the semiconductor device emits a radiation having a peak wavelength between 800 nm and 2000 nm.

• 출원번호 : 18896886
• 출원인 : CHEN, Meng-Yang
• 특허번호 :
• IPC : H01L-033/00(2006.01);H01L-033/04(2006.01);H01L-033/10(2006.01);H01L-033/30(2006.01);H01L-033/62(2006.01);

PROBLEM TO BE SOLVED: To provide an EMR base system effectively treating pigmentation of the skin.SOLUTION: A system includes a focus optic system configured to converge an electromagnetic radiation (EMR) beam to a focal region located along an optical axis. The system also includes a detector configured to detect a signal radiation emanating from a predetermined location along the optical axis. The system additionally includes a controller configured to adjust a parameter of the EMR beam based in part on the signal radiation detected by the detector. The system also includes a window located a predetermined depth away from the focal region between the focal region and the focus optic system along the optical axis, wherein the window is configured to make contact with a surface of a tissue.SELECTED DRAWING: Figure 5

• 출원번호 : 2024166809
• 출원인 : AVAVA INC
• 특허번호 :
• IPC : A61N-005/067(2006.01)

A system, method, device and computer program are provided for determining a physiological parameter of a body comprising blood perfused tissue. The system comprises a sensor, or a plurality of sensors. The sensor(s) receive first and second radiation from the blood perfused tissue. The sensor(s) generate a first signal relating to an amount of blood (x(t)), and a second signal relating to a speed of blood (v(t)). An evaluation unit of the system defines first and second signal fractions in the first and second signals, respectively. The evaluation unit performs an intrinsic check whether to accept or reject the signal fractions and optionally uses a cross-check algorithm that has as its input both signal fractions and the result of the intrinsic check. The physiological parameter is determined using, if the cross-check algorithm was performed, the first and/or second signal fraction if accepted by the cross-check algorithm.

• 출원번호 : EP2024/076899
• 출원인 : SONION NEDERLAND B.V.
• 특허번호 :
• IPC : A61B-005/021(2006.01);A61B-005/0215(2006.01);A61B-005/026(2006.01);A61B-005/0295(2006.01);A61B-005/00(2006.01);

PROBLEM TO BE SOLVED: To provide a terahertz (THz) apparatus for transmitting and/or receiving THz radiation.SOLUTION: A terahertz (THz) apparatus for transmitting and/or receiving THz radiation is provided, comprising at least one THz element designed to transmit and/or receive THz radiation, and a digital data processing device designed to at least temporarily process a first signal of at least one component of the apparatus.SELECTED DRAWING: Figure 1

• 출원번호 : 2024166430
• 출원인 : HELMUT FISCHER GMBH INST FUER ELEKTRONIK & MESSTECHNIK
• 특허번호 :
• IPC : G01S-007/484(2006.01);G01B-015/02(2006.01);G01S-007/282(2006.01);

Described herein are systems and methods for providing output radiation, the systems and methods comprising broadening and/or temporally shortening radiation to produce the output radiation. The systems and methods may comprise broadening and/or temporally shortening two radiation beams having different wavelengths, for example a pump radiation beam and a converted (e.g. second harmonic) radiation beam.

• 출원번호 : EP2024/076876
• 출원인 : ASML NETHERLANDS B.V.
• 특허번호 :
• IPC : G02F-001/35(2006.01)

Molding method suitable for making a first component (1 ), comprising at least: a first deposition step of a first mixture (4) on a second surface (30) inside a mold (3) for molding, said first mixture (4) comprising at least a detaching agent (5) suitable for promoting the detachment of said first component (1 ) from said mold (3); a second deposition step wherein a second mixture (7) is deposited at least on predetermined second zones (31 ) of said second surface (30); said second mixture (7) comprising a photoinitiator (9); a filling step wherein said mold (3) is filled with a material (6); a molding step wherein said material (6) in said mold (3) is transformed into said first component (1 ), and said first mixture (4) is present on a first surface (10) of said first component (1 ); an extraction step wherein said first component (1 ) is extracted from said mold (3); and an irradiation step, subsequent to said extraction step, wherein at least some first zones (11 ) of said first surface (10), said first zones (11 ) being facing said second zones (31 ) when said first component (1 ) is contained in said mold (3), are irradiated with electromagnetic radiation capable of activating said photoinitiator (9) and said first mixture (4) undergoes a chemical transformation.

• 출원번호 : IB2024/059324
• 출원인 : TOSCANA GOMMA S.P.A.
• 특허번호 :
• IPC : B29C-033/58(2006.01);B29C-035/08(2006.01);B29C-037/00(2006.01);B29K-075/00(2006.01);B29L-031/58(2006.01);

The disclosure concerns a communication system where adaptive antenna systems with algorithm are used to provide improved channel selection management in Wireless Local Area Network (WLAN) and other multi-node communication systems. The adaptive antenna systems can be integrated into multiple nodes of a communication network, such as access points used in WLAN, and multiple radiation modes generated and tracked to determine optimal mode for access point to client communication links to assist in channel selection across the nodes in the network. Adaptive antenna system modes are selected and Signal to Noise Ratio (SNR) is measured across available frequency channels to determine channels to assign per access point along with radiation modes to be implemented that results in improved SNR for the communication links established in the network.

• 출원번호 : 18896179
• 출원인 : Pajona, Olivier
• 특허번호 :
• IPC : H04W-072/54(2006.01);H04W-024/02(2006.01);H04W-072/542(2006.01);H04W-072/543(2006.01);H04W-084/12(2006.01);

The present invention relates to a method of decontaminating metal surfaces in a cooling system of a nuclear reactor, wherein the metal surfaces are coated with a solid metal oxide layer including radionuclides.

• 출원번호 : EP2024/076722
• 출원인 : FRAMATOME GMBH
• 특허번호 :
• IPC : G21F-009/00(2006.01);G21F-009/30(2006.01);G21C-017/022(2006.01);C23G-001/02(2006.01);C23G-001/14(2006.01);G21F-009/12(2006.01);