The present invention relates a composition for use in increasing the longevity and/or enhancing healthy aging of a subject, particularly a human subject, and methods thereof. The composition comprises at least one of: isoscabertopin; 1,7-Bis (hydroxyphenyl)-4-hepten-3-one; eupafolin; isokuranetin, (E) - aldosecologanin, or any combination thereof, and increases expression of or activates a transcription factor selected from the group consisting of: nuclear factor (erythroid-derived 2)-like 2 (NRF2), Forkhead box O3 (FOXO3) and Grainy head 1 (GRHL1). Non-therapeutic or therapeutic uses and methods are disclosed herein. The extending longevity includes stimulating innate immunity, resistance against oxidative stress, inhibition of tumor cell growth, treating or preventing age-related diseases and disorders, which include: inflammation and inflammatory diseases, non-communicable diseases including: cardiovascular diseases, arthropathies, cancer, neurodegenerative diseases, diabetes, frailty, decline of physical fitness, decline of physical endurance or combinations thereof.
- 출원번호 : EP2025/075524
- 출원인 : MJN U.S. HOLDINGS LLC;RECKITT BENCKISER HEALTH LIMITED;
- 특허번호 :
- IPC : A61K-036/28(2006.01);A61K-031/343(2006.01);A61K-031/352(2006.01);A61K-031/365(2006.01);A61P-005/00(2006.01);A61P-009/00(2006.01);A61P-029/00(2006.01);A61P-035/00(2006.01);