Provided here are nuclear receptor 4A agonists and methods of use for treatment of an infectious disease or an inflammation-related disease. These agonists include 3-(adamantan-1-yl)-1-(2-hydroxy-2-phenylpropyl)urea (available at Life Chemicals as F6279-0659), N-(3-acetylphenyl)-5,6,7,8-tetrahydronaphthalene-2-carboxamide (available at Life Chemicals as F0537-0485), N-(1-hydroxy-2,3-dihydro-1H-inden-1-yl)methylnaphthalene-1-carboxamide (available at Life Chemicals as F5857-5371), 3,4-difluoro-N-(2-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)methylbenzamide (available at Life Chemicals as F6414-1064), N-(3-hydroxy-3-phenylpropyl)naphthalene-1-carboxamide (available at Life Chemicals as F5857-6887), N-(2-hydroxy-3-phenylpropyl)naphthalene-1-carboxamide (available at Life Chemicals as F6200-1091) or a pharmaceutically acceptable salt thereof. These agonists include one or more of F5964-0242, F5964-0253, F1065-0517, F0020-1803, F5857-5401, F0915-2916, F0307-0288, F3350-0754, F6172-0216, F3367-0092, F6172-0224, F5857-2441, F5857-6404, and F5857-5470 (available at Life Chemicals) or a pharmaceutically acceptable salt or derivative thereof.
- 출원번호 : 19312265
- 출원인 : Schlesinger, Larry S.
- 특허번호 :
- IPC : A61K-031/17(2006.01);A61K-031/165(2006.01);A61K-031/166(2006.01);A61K-031/167(2006.01);A61K-031/192(2006.01);A61K-031/194(2006.01);A61K-031/498(2006.01);A61K-045/06(2006.01);